Cognitive Health: EGb 761® Study Reveals Bioactive Role of Proanthocyanidins

2025-10-28
Ginkgo leaf magnified by a stereo microscope

We’re excited to share our latest research published in Frontiers in Pharmacology – Ethnopharmacology exploring a previously underappreciated component of Ginkgo biloba—proanthocyanidins (PACs)—and their contribution to cognitive health.

While Ginkgo extracts are adjusted for flavonols and terpene lactones, PACs have remained a bit of a mystery. Our study sheds light on their antioxidative potency, bioavailability, and antiamnesic effects using both in vitro and in vivo models.

🔍 Key findings:

  • PACs showed strong antioxidative activity in neuronal cells.
  • In a mouse model, PACs and EGb 761® similarly reversed scopolamine-induced memory impairment.
  • PAC-derived metabolites were detected early post-administration, suggesting direct pharmacological relevance.
  • Ginkgo products with higher PAC content demonstrated superior efficacy in both models.

These results support the hypothesis that PACs are active contributors to the therapeutic effects of EGb 761®—a significant step forward in understanding the full spectrum of Ginkgo biloba’s pharmacology. A big thanks to our Preclinical R&D team at Schwabe for this outstanding research!

Read the full study https://www.frontiersin.org/articles/10.3389/fphar.2025.1673248