A milestone in phytomedicine: clinical trial proves efficacy of Silexan® in depression


A recent publication reports on our international clinical trial to demonstrate the efficacy and safety of Silexan®, a proprietary lavender oil preparation, in the treatment of mild to moderate depressive episodes.

A total of 498 patients with a diagnosis of mild to moderate depressive disorder were treated for 8 weeks with either Silexan®, placebo (i.e., a dummy drug) or sertraline (i.e., an established synthetic prescription antidepressant). At the end of treatment, the depressive symptoms had improved considerably and statistically significantly more with Silexan® treatment compared to placebo treatment. The antidepressant effects of Silexan were clinically significant and as convincing as those of sertraline.

Thus, these new and clinically highly relevant results prove the antidepressant efficacy of Silexan®, a proprietary lavender oil preparation, in mild or moderate major depressive disorder.

The high-ranking original publication can be read here: https://link.springer.com/article/10.1007/s00406-024-01783-2

Kasper S, Volz HP, Möller HJ, Schläfke S, Klement S, Anghelescu IG, Seifritz E. Lavender oil preparation Silexan is effective in mild-to-moderate major depression: a randomized, placebo- and reference-controlled trial. Eur Arch Psychiatry Clin Neurosci. 2024 Apr 1. doi: 10.1007/s00406-024-01783-2. Epub ahead of print. PMID: 38558147.